Antigen Information
General Information of This Antigen (ID: TAR0RYGBQ)
| Antigen Name | Claudin-6 (CLDN6); Claudin-9 (CLDN9) |
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| Gene Name | CLDN6; CLDN9 |
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| Gene ID | ||||||
| Synonym1 | Claudin-6, Skullin |
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| Synonym2 | Claudin-9 |
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| Sequence1 |
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG
QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV Click to Show/Hide
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| Sequence2 |
MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG
QMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLT AGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGL LCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV Click to Show/Hide
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| Family1 | Claudin family |
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| Family2 | Claudin family |
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| Function1 |
Plays a major role in tight junction-specific obliteration of the intercellular space.
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| Function2 |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
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| Uniprot Entry | ||||||
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
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An antibody targeting CLDN6/9
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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SC-004
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SGD-1882 |
Human deoxyribonucleic acid (hDNA) |
Val-Cit linker |
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SHR-7782
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Undisclosed |
Undisclosed |
Undisclosed |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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BLB-101
[1]
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Undisclosed |
Undisclosed |
Undisclosed |
References