Antigen Information

General Information of This Antigen
Antigen ID
TAR0RTOLA
Antigen Name
Aspartyl/asparaginyl beta-hydroxylase (ASPH)
Gene Name
ASPH
Gene ID
444
Synonym
BAH; Aspartate beta-hydroxylase;Peptide-aspartate beta-dioxygenase
Sequence
MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMV
IALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVP
PEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQ
QEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSE
PVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSI
FPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEA
VNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLK
LSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEV
LSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGN
KEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDE
GLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGC
RRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFD
DSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI

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Family
APP family
Function
Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.

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Uniprot Entry
ASPH_HUMAN
HGNC ID
HGNC:757
KEGG ID
hsa:444
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PAN-622-toxin conjugate
Undisclosed
Undisclosed
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SNS-622-DM1
Mertansine DM1
Microtubule (MT)
Maleimido-caproyl
 [2]
 ADC Info 
SNS-622-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
 ADC Info 
SNS-622-DUO
Duocarmycin A
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Cit-PABC
 [2]
References
Ref 1 Introduction to basic information on ADC drug PAN-622-toxin conjugate(Sensei Biotherapeutics).
Ref 2 Anti-tumor activity of antibody drug conjugate targeting aspartate--hydroxylase in pancreatic ductal adenocarcinoma. Cancer Lett. 2019 May 1;449:87-98. doi: 10.1016/j.canlet.2019.02.006. Epub 2019 Feb 12.