Antigen Information

General Information of This Antigen
Antigen ID
TAR0QEXPC
Antigen Name
Leucine-rich repeat-containing protein 15 (LRRC15)
Gene Name
LRRC15
Gene ID
131578
Synonym
LIB; Leucine-rich repeat protein induced by beta-amyloid homolog
Sequence
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI
LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL
FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL
GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL
FHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWL
YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV
FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL
YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE
VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA
IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC

    Click to Show/Hide
Uniprot Entry
LRC15_HUMAN
HGNC ID
HGNC:20818
KEGG ID
hsa:131578
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-LRRC15 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZL-6201
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 [1]
huAD208.14.1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuAD208.14.1-vcMMAE-DAR4
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
huAD208.4.1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuAD208.4.1-vcMMAE-DAR4
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
 ADC Info 
HuAD208.4.1-PBD-DAR2
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuM25-vcMMAE-E2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
 ADC Info 
HuM25-vcMMAE-DAR4
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
 ADC Info 
HuM25-mcMMAF-E2
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
huM25-vcMMAE ADCs
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
 ADC Info 
Anti-huLRRC15 ADCs
Monomethyl auristatin F
Microtubule (MT)
6-Maleimidocaproic acid
 [3]
 ADC Info 
Anti-huLRRC15 PBD ADCs
PBD
Undisclosed
Mc-Val-Cit-PABC
 [3]
huM25-S239C
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuM25-S239C-PBD-E2
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 [2]
Samrotamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Samrotamab vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
RAD-502
Undisclosed
Undisclosed
Undisclosed
 [4]
References
Ref 1 Discovery and characterization of a novel LRRC15-targeting antibody drug conjugate (ADC) for the treatment of solid tumors
Ref 2 Anti-huLRRC15 antibody drug conjugates and methods for their use. 2017-06-08
Ref 3 Anti-huLRRC15 antibody drug conjugates and methods for their use
Ref 4 Introduction to basic information on ADC drug RAD-502.