Antigen Information

General Information of This Antigen (ID: TAR0QEXPC)
Antigen Name
Leucine-rich repeat-containing protein 15 (LRRC15)
Gene Name
LRRC15
Gene ID
131578
Synonym
LIB; Leucine-rich repeat protein induced by beta-amyloid homolog
Sequence
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI
LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL
FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL
GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL
FHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWL
YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV
FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL
YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE
VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA
IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC

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Uniprot Entry
LRC15_HUMAN
HGNC ID
HGNC:20818
KEGG ID
hsa:131578
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-LRRC15 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZL-6201 [1]
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
huAD208.14.1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuAD208.14.1-vcMMAE-DAR4 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
huAD208.4.1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuAD208.4.1-vcMMAE-DAR4 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
HuAD208.4.1-PBD-DAR2 [2]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
ADC Name Payload Target Linker ADC Info
HuM25-vcMMAE-E2 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
HuM25-vcMMAE-DAR4 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
HuM25-mcMMAF-E2 [2]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
ADC Name Payload Target Linker ADC Info
huM25-vcMMAE ADCs [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-huLRRC15 ADCs [3]
Monomethyl auristatin F
Microtubule (MT)
6-Maleimidocaproic acid
 ADC Info 
Anti-huLRRC15 PBD ADCs [3]
PBD
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
huM25-S239C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuM25-S239C-PBD-E2 [2]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
Samrotamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Samrotamab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RAD-502 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Discovery and characterization of a novel LRRC15-targeting antibody drug conjugate (ADC) for the treatment of solid tumors
Ref 2 Anti-huLRRC15 antibody drug conjugates and methods for their use. 2017-06-08
Ref 3 Anti-huLRRC15 antibody drug conjugates and methods for their use
Ref 4 Introduction to basic information on ADC drug RAD-502.