Antigen Information

General Information of This Antigen (ID: TAR0PQIJF)
Antigen Name
Cadherin-17 (CDH17)
Gene Name
CDH17
Gene ID
1015
Synonym
Intestinal peptide-associated transporter HPT-1;Liver-intestine cadherin
Sequence
MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF
ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN
DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF
QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK
APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR
EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG
TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL
TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP
FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV
FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY
SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV
NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK
INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT
GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS

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Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

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Uniprot Entry
CAD17_HUMAN
HGNC ID
HGNC:1756
KEGG ID
hsa:1015
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CDH17 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AMT-676
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 ADC Info 
HDM2017 [1]
CPT-derivative payloads
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
YL217
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
DB-1324
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HS-20110
HS-9265
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
SIM0609
CPT116
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-CDH17 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CM518D1
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MRG007
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-CDH17 mAb ARB102
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ARB102-IR700 [2]
IRDye 700DX
Undisclosed
Undisclosed
 ADC Info 
Fully humanized anti-CDH17 monoclonal antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BSI-721 [3]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
humanized CDH17 IgG1 monoclonal antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LBL-054 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
LBL-054-Dxd [4]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
LM-350 [5]
LDX2
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
7MW4911
Mtoxin
DNA topoisomerase 1 (TOP1)
A cleavable disulfide linker
 ADC Info 
Zarutatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Zarutatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PA-368B [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PA-368A [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
SCR-A008 [8]
CPT116
Undisclosed
Undisclosed
 ADC Info 
BR116 [9]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
SOT109 [10]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
References
Ref 1 Discovery of HDM2017, a CDH17-targeting ADC for colorectal cancers
Ref 2 Cadherin-17 Targeted Near-Infrared Photoimmunotherapy for Treatment of Gastrointestinal Cancer. Mol Pharm. 2020 Oct 5;17(10):3941-3951. doi: 10.1021/acs.molpharmaceut.0c00700. Epub 2020 Sep 24.
Ref 3 Development and preclinical activity of BSI-721, a novel antibody-drug conjugate (ADC) targeting cadherin 17 (CDH17) in gastrointestinal cancers
Ref 4 Novel hydrophilic CDH17-targeting antibody-drug conjugate exhibits anti-tumor efficacy in preclinical xenograft models
Ref 5 Preclinical evaluation of LM-350: An innovative anti-CDH17 antibody drug conjugate for gastrointestinal cancer therapy
Ref 6 Introduction to basic information on ADC drug PA-368B
Ref 7 Introduction to basic information on ADC drug PA-368A
Ref 8 Preclinical development of SCR-A008: A CDH17-targeted ADC for gastrointestinal cancer
Ref 9 BR116: An antibody drug conjugate targeting CDH17 for gastrointestinal cancer therapy
Ref 10 Preclinical safety and efficacy of SOT109, an antibody-drug conjugate targeting cadherin 17 (CDH17) for the treatment of colorectal and other gastrointestinal tract tumors