Antigen Information

General Information of This Antigen
Antigen ID
TAR0PQIJF
Antigen Name
Cadherin-17 (CDH17)
Gene Name
CDH17
Synonym
Intestinal peptide-associated transporter HPT-1;Liver-intestine cadherin
Sequence
MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTF
ELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDIN
DNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINNVMYF
QINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFSDTTSVDIIVTENIWK
APKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDKEKLPRFPFSIDQEGDIYVTQPLDR
EEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIG
TLTAHDRDEENTANSFLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNL
TIEVSDKDFKTLCFVQINVIDINDQIPIFEKSDYGNLTLAEDTNIGSTILTIQATDADEP
FTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIKKPLDFETAAVSNIVFKAENPEPLV
FGVKYNASSFAKFTLIVTDVNEAPQFSQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISY
SLRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDV
NDNPPRLAKDYTGLFFCHPLSAPGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSK
INGTHARLSTRHTEFEEREYVVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQT
GIPTVGMAVGILLTTLLVIGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS

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Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

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Uniprot Entry
CAD17_HUMAN
HGNC ID
HGNC:1756
KEGG ID
hsa:1015
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CDH17 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AMT-676
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 ADC Info 
HDM2017
CPT-derivative payloads
DNA topoisomerase 1 (TOP1)
Undisclosed
 [1]
 ADC Info 
yL217
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
dB-1324
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hS-20110
HS-9265
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
sIM0609
CPT116
DNA topoisomerase 1 (TOP1)
A cleavable linker
Anti-CDH17 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
cM518D1
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
mRG007
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
Anti-CDH17 mAb ARB102
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ARB102-IR700
IRDye 700DX
Undisclosed
Undisclosed
 [2]
Fully humanized anti-CDH17 monoclonal antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BSI-721
Monomethyl auristatin E
Undisclosed
Undisclosed
 [3]
humanized CDH17 IgG1 monoclonal antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
LBL-054
Undisclosed
Undisclosed
Undisclosed
 [4]
 ADC Info 
LBL-054-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
 [4]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
LM-350
LDX2
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [5]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
7MW4911
Mtoxin
DNA topoisomerase 1 (TOP1)
A cleavable disulfide linker
Zarutatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Zarutatug vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PA-368B
Undisclosed
Undisclosed
Undisclosed
 [6]
 ADC Info 
PA-368A
Undisclosed
Undisclosed
Undisclosed
 [7]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SCR-A008
CPT116
Undisclosed
Undisclosed
 [8]
 ADC Info 
BR116
Undisclosed
Undisclosed
Undisclosed
 [9]
 ADC Info 
SOT109
Exatecan
Undisclosed
Undisclosed
 [10]
References
Ref 1 Discovery of HDM2017, a CDH17-targeting ADC for colorectal cancers
Ref 2 Cadherin-17 Targeted Near-Infrared Photoimmunotherapy for Treatment of Gastrointestinal Cancer. Mol Pharm. 2020 Oct 5;17(10):3941-3951. doi: 10.1021/acs.molpharmaceut.0c00700. Epub 2020 Sep 24.
Ref 3 Development and preclinical activity of BSI-721, a novel antibody-drug conjugate (ADC) targeting cadherin 17 (CDH17) in gastrointestinal cancers
Ref 4 Novel hydrophilic CDH17-targeting antibody-drug conjugate exhibits anti-tumor efficacy in preclinical xenograft models
Ref 5 Preclinical evaluation of LM-350: An innovative anti-CDH17 antibody drug conjugate for gastrointestinal cancer therapy
Ref 6 Introduction to basic information on ADC drug PA-368B
Ref 7 Introduction to basic information on ADC drug PA-368A
Ref 8 Preclinical development of SCR-A008: A CDH17-targeted ADC for gastrointestinal cancer
Ref 9 BR116: An antibody drug conjugate targeting CDH17 for gastrointestinal cancer therapy
Ref 10 Preclinical safety and efficacy of SOT109, an antibody-drug conjugate targeting cadherin 17 (CDH17) for the treatment of colorectal and other gastrointestinal tract tumors