Antigen Information

General Information of This Antigen
Antigen ID
TAR0OFMSA
Antigen Name
40S ribosomal protein SA (RPSA)
Gene Name
RPSA
Gene ID
3921
Synonym
LAMBR; LAMR1; 37 kDa laminin receptor precursor;37/67 kDa laminin receptor;67 kDa laminin receptor;Colon carcinoma laminin-binding protein;Laminin receptor 1;Laminin-binding protein precursor p40;Multidrug resistance-associated protein MGr1-Ag;NEM/1CHD4;Small ribosomal subunit protein uS2
Sequence
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR
LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR
EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS

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Family
Universal ribosomal protein uS2 family
Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.

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Uniprot Entry
RSSA_HUMAN
HGNC ID
HGNC:6502
KEGG ID
hsa:3921
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-laminin receptor IgM
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-Laminin receptor monoclonal antibody-liposomal doxorubicin conjugate
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Disulfide bond linker
 [1]
References
Ref 1 Anti-laminin receptor antibody targeting of liposomes with encapsulated doxorubicin to human breast cancer cells in vitro. J Natl Cancer Inst. 1989 Dec 6;81(23):1794-800. doi: 10.1093/jnci/81.23.1794.

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