Antigen Information

General Information of This Antigen (ID: TAR0OFMSA)
Antigen Name
Small ribosomal subunit protein uS2 (RPSA)
Gene Name
RPSA
Gene ID
3921
Synonym
LAMBR; LAMR1; 37 kDa laminin receptor precursor;37/67 kDa laminin receptor;67 kDa laminin receptor;Colon carcinoma laminin-binding protein;Laminin receptor 1;Laminin-binding protein precursor p40;Multidrug resistance-associated protein MGr1-Ag;NEM/1CHD4;Small ribosomal subunit protein uS2
Sequence
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR
LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR
EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS

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Family
Universal ribosomal protein uS2 family
Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.

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Uniprot Entry
RSSA_HUMAN
HGNC ID
HGNC:6502
KEGG ID
hsa:3921
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-laminin receptor IgM
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-Laminin receptor monoclonal antibody-liposomal doxorubicin conjugate [1]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Disulfide bond linker
 ADC Info 
References
Ref 1 Anti-laminin receptor antibody targeting of liposomes with encapsulated doxorubicin to human breast cancer cells in vitro. J Natl Cancer Inst. 1989 Dec 6;81(23):1794-800. doi: 10.1093/jnci/81.23.1794.