Antigen Information

General Information of This Antigen (ID: TAR0NNDBO)
Antigen Name
Endoplasmin homolog (LPG3)
Gene Name
LPG3
Synonym
GRP94
Sequence
MANSSLLRVVLVALLLLGSVTVSAGDGRGTPIAFQAEVSKMLDILVNSLYTNRAVFLREL
ISNGSDALDKIRVLYLTSPKEPLTKDGEAPTMDLRISFDKEKSELILRDGGVGMTKEELA
KHLGSLGTSGTKHFLEKLQEGVGAVGGDQNNLIGQFGVGFYSVFLVGDRVRVASKSDDSD
EQYVWESKGDGQYFLYPDPRGNTLGRGTEITIELKPDAEQFLSAETIKKTIHQYSEFINF
PIYVQEEVEVASTAATPESAAEERSLDEGAVEEDPDKEGDTQGVVKEKRWTLVNENRPIW
TRPIGNVTEEEYHKFYKAFSGDYRDPLYFNHFKVEGEVDFDSILFVPTTVDPASFSDDNA
VPNTNIKLYVRRVFITDEFRDLLPRYLNFVKGIVDSNDLPLNVSREVLQESRILRVIKKK
LVRKTLSMFADIAAQDEAIANGKQVENPAPSGHTHLKKPAYTKFWELYGKHLRLGVMLDS
NNRNRLTKLFRYKSSRSESEYISLQTYVDRMKKGQKGIYYLSGDSVARIKKSPVLEDAVN
HDVEVIFMTDAIDEYVVSQLTDFAGKKLINLAKEGVQFEESDARQRVVDRKRKEKYDSFF
THLRALFGYSEVRKVILTKRMTNEAFIVSSSENQITARLASIMRGQSMSLANQQLTAERV
LEVNYRHPLVDEMFKRFTVDEDDEVATDIAWVLYDTANLQAEFPVADVAAYSKRINRLLR
SSVDLSADDSLLPPDDAEYTVSDTETEEEEEQPKVDTNAHEEAETDGEGDL

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Family
Heat shock protein 90 family
Function
FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Required for the synthesis of lipophosphoglycan (LPG), a cell surface glycoconjugate (PubMed:12198148). Necessary for the attachment of the galactosyl residue to the mannose within the phosphoglycan repeats of the nascent LPG chain (PubMed:12198148). Also required for addition of phosphoglycan to acid phosphatase (PubMed:12198148). Not required for normal growth (PubMed:12198148). Has ATPase activity (By similarity). Binds heparin with micromolar affinity which may facilitate infection of host cells (By similarity). {ECO:0000250|UniProtKB:P08113, ECO:0000250|UniProtKB:Q9NGD0, ECO:0000269|PubMed:12198148}.

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Uniprot Entry
ENPL_LEIDO
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
KR1020240043161A 3G7-Sec-DM1 [1]
Mertansine DM1
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 Antibody binding specifically to GRP94 or antibody drug conjugate containing his antigen binding fragment and drug