Antigen Information
General Information of This Antigen
| Antigen ID | TAR0NFRAT |
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| Antigen Name | TNF receptor superfamily member 1B (TNFRSF1B) |
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| Gene Name | TNFRSF1B |
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| Synonym | TNFR2 |
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| Sequence |
OX=9606GN=TNFRSF1BPE=1SV=3MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAP
EPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECL SCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGT ETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAV HLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLL IIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESS ASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHS SQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVP DAGMKPS Click to Show/Hide
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| Function |
Receptor with high affinity for TNFSF2/TNF-alpha and; approximately 5-fold lower affinity for homotrimeric; TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the; apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor; mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks; TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha; function by antagonizing its biological activity.
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Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
TP-3 murine mAb
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
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Monoclonal antibody TP3-PAP conjugate |
Pokeweed antiviral protein (PAP) |
Ribosome (RB) |
Undisclosed |
[1] |