Antigen Information
General Information of This Antigen (ID: TAR0NFRAT)
| Antigen Name | TNF receptor superfamily member 1B (TNFRSF1B) |
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| Gene Name | TNFRSF1B |
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| Gene ID | ||||||
| Synonym | TNFR2 |
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| Sequence |
OX=9606GN=TNFRSF1BPE=1SV=3MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAP
EPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECL SCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGT ETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAV HLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLL IIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESS ASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHS SQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVP DAGMKPS Click to Show/Hide
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| Function |
Receptor with high affinity for TNFSF2/TNF-alpha and; approximately 5-fold lower affinity for homotrimeric; TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the; apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor; mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks; TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha; function by antagonizing its biological activity.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
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TP-3 murine mAb
| ADC Name | Payload | Target | Linker | ADC Info |
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Monoclonal antibody TP3-PAP conjugate
[1]
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Pokeweed antiviral protein (PAP) |
Ribosome (RB) |
Undisclosed |