Antigen Information

General Information of This Antigen
Antigen ID
TAR0MVKGL
Antigen Name
GDNF family receptor alpha-1 (GFRA1)
Gene Name
GFRA1
Gene ID
2674
Synonym
GDNFRA; RETL1; TRNR1; RET ligand 1;TGF-beta-related neurotrophic factor receptor 1
Sequence
MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNF
SLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSP
YEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT
SVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREK
PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPN
YIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPV
QTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNY
EKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS

    Click to Show/Hide
Family
Folate receptor family
Function
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

    Click to Show/Hide
Uniprot Entry
GFRA1_HUMAN
HGNC ID
HGNC:4243
KEGG ID
hsa:2674
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-GFRA1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
GFRA1 targeted antibody-drug conjugate
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 [1]
References
Ref 1 Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer. Oncotarget. 2018 May 1;9(33):22960-22975. doi: 10.18632/oncotarget.25160. eCollection 2018 May 1.