Antigen Information

General Information of This Antigen (ID: TAR0MQVPS)
Antigen Name
Tubulin alpha 1B (TUBA1B)
Gene Name
TUBA1B
Gene ID
10376
Sequence
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

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Family
Tubulin family
Function
Tubulin is the major constituent of microtubules, a cylinder; consisting of laterally associated linear protofilaments composed of; alpha- and beta-tubulin heterodimers. Microtubules; grow by the addition of GTP-tubulin dimers to the microtubule end,; where a stabilizing cap forms. Below the cap, tubulin; dimers are in GDP-bound state, owing to GTPase activity of alpha; tubulin.

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Uniprot Entry
TBA1B_HUMA
HGNC ID
HGNC:18809
KEGG ID
hsa:10376
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
Monoclonal antibody 1H10-doxorubicin conjugate [1]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Dextran
 ADC Info 
References
Ref 1 Doxorubicin: monoclonal antibody conjugate for therapy of human cervical carcinoma. Int J Cancer. 1992 May 8;51(2):274-82. doi: 10.1002/ijc.2910510217.