Antigen Information

General Information of This Antigen (ID: TAR0LLYTK)
Antigen Name
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Gene Name
TNFSF10
Gene ID
8743
Synonym
APO2L; TRAIL; Apo-2 ligand;TNF-related apoptosis-inducing ligand;CD253
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

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Family
Tumor necrosis factor family
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

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Uniprot Entry
TNF10_HUMAN
HGNC ID
HGNC:11925
KEGG ID
hsa:8743
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AD-064.4 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
B-1453 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
References
Ref 1 Introduction to basic information on ADC drug AD-064.4.
Ref 2 Tasly pharma announcement; 2020