Antigen Information

General Information of This Antigen
Antigen ID
TAR0LLYTK
Antigen Name
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Gene Name
TNFSF10
Synonym
APO2L; TRAIL; Apo-2 ligand;TNF-related apoptosis-inducing ligand;CD_antigen=CD253
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

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Family
Tumor necrosis factor family
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

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Uniprot Entry
TNF10_HUMAN
HGNC ID
HGNC:11925
KEGG ID
hsa:8743
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AD-064.4
Undisclosed
Undisclosed
Undisclosed
 [1]
 ADC Info 
B-1453
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
References
Ref 1 Introduction to basic information on ADC drug AD-064.4.
Ref 2 Tasly pharma announcement; 2020