Antigen Information
General Information of This Antigen (ID: TAR0LEENM)
| Antigen Name | Interleukin-7 receptor subunit alpha (IL7R) |
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| Gene Name | IL7R |
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| Gene ID | ||||||
| Synonym | CDw127;CD127 |
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| Sequence |
MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFE
DPDVNITNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKK IDLTTIVKPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTH VNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDP ILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNP ESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPES FGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFS LQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ Click to Show/Hide
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| Family | Cytokine receptor type I family |
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| Function |
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Anti-IL7R mAb A7R
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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A7R-ADC-SN38
[1]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mal-PEG12-carbamate-PEG27 |
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A7R-ADC-MMAE
[1]
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Monomethyl auristatin E |
Microtubule (MT) |
Mal-PEG12-Val-Cit-PABC |
References