Antigen Information

General Information of This Antigen
Antigen ID
TAR0LEENM
Antigen Name
Interleukin-7 receptor subunit alpha (IL7R)
Gene Name
IL7R
Synonym
CDw127;CD_antigen=CD127
Sequence
MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFE
DPDVNITNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKK
IDLTTIVKPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTH
VNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDP
ILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNP
ESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPES
FGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFS
LQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ

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Family
Cytokine receptor type I family
Function
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

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Uniprot Entry
IL7RA_HUMAN
HGNC ID
HGNC:6024
KEGG ID
hsa:3575
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-IL7R mAb A7R
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
A7R-ADC-SN38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Mal-PEG12-carbamate-PEG27
 [1]
 ADC Info 
A7R-ADC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG12-Val-Cit-PABC
 [1]
References
Ref 1 Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease. Sci Rep. 2017 Sep 6;7(1):10735. doi: 10.1038/s41598-017-11255-4.