Antigen Information
General Information of This Antigen (ID: TAR0KXLAK)
| Antigen Name | Basal cell adhesion molecule (BCAM) |
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| Gene Name | BCAM |
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| Gene ID | ||||||
| Synonym | LU; MSK19 |
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| Sequence |
MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD
HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPGLSHSGS EQPEQTGLLMGGASGGARGGSGGFGDEC Click to Show/Hide
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| Function |
FUNCTION: Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
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HG4K
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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HG4K IgG4-Linker-DM1
[1]
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Undisclosed |
Undisclosed |
Undisclosed |
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HG4K IgG4-Linker-AF
[1]
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Undisclosed |
Undisclosed |
Undisclosed |
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HG4K IgG4-Linker-MMAF
[1]
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Undisclosed |
Undisclosed |
Undisclosed |
HG4K IgG4
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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HG4K IgG4-Linker-DM1 (2)
[1]
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Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
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HG4K IgG4-Linker-AF (1)
[1]
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CL202203715A1 AF |
Undisclosed |
Undisclosed |
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HG4K IgG4-Linker-MMAF (3)
[1]
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Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |