Antigen Information
General Information of This Antigen
| Antigen ID | TAR0KXLAK |
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| Antigen Name | Basal cell adhesion molecule (BCAM) |
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| Gene Name | BCAM |
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| Synonym | LU; MSK19 |
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| Sequence |
MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHD
HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDE RDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPA PKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAH YSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPE YTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAY LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG TYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPD PKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTV SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPGLSHSGS EQPEQTGLLMGGASGGARGGSGGFGDEC Click to Show/Hide
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| Function |
FUNCTION: Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}.
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Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
HG4K
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
hG4K IgG4-Linker-DM1 |
Undisclosed |
Undisclosed |
Undisclosed |
[1] | |
hG4K IgG4-Linker-AF |
Undisclosed |
Undisclosed |
Undisclosed |
[1] | |
hG4K IgG4-Linker-MMAF |
Undisclosed |
Undisclosed |
Undisclosed |
[1] |
HG4K IgG4
| ADC Info | ADC Name | Payload | Target | Linker | Ref |
|---|---|---|---|---|---|
HG4K IgG4-Linker-DM1 (2) |
Mertansine DM1 |
Undisclosed |
Undisclosed |
[1] | |
HG4K IgG4-Linker-AF (1) |
CL202203715A1 AF |
Undisclosed |
Undisclosed |
[1] | |
HG4K IgG4-Linker-MMAF (3) |
Monomethyl auristatin F |
Microtubule (MT) |
Undisclosed |
[1] |