Antigen Information

General Information of This Antigen
Antigen ID
TAR0JXPTV
Antigen Name
Inactive tyrosine-protein kinase 7 (PTK7)
Gene Name
PTK7
Synonym
CCK4; Colon carcinoma kinase 4;Protein-tyrosine kinase 7;Pseudo tyrosine kinase receptor 7;Tyrosine-protein kinase-like 7
Sequence
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG
RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP

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Family
Tyr protein family
Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

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Uniprot Entry
PTK7_HUMAN
HGNC ID
HGNC:9618
KEGG ID
hsa:5754
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
(undisclosed)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
6-Dec
CPT113
DNA topoisomerase 1 (TOP1)
Highly stable yet cleavable linker
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MTX-13
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 [1]
Anti-PTK7 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PRO1107
MMAE
Microtubule (MT)
A cleavable linker
 ADC Info 
sKB518
KL610348
DNA topoisomerase 1 (TOP1)
Kthiol (pyrimidine-thiol) GGFG linker
Anti-PTK7 IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
kIVU-107
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
Anti-PTK7 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
lY4175408
Exatecan
DNA topoisomerase 1 (TOP1)
A proprietary polysarcosine hydrophobicity linker
Cofetuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Cofetuzumab pelidotin
Auristatin 0101 (Aur0101)
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC1-2
ADC 1-2 payload
DNA topoisomerase 1 (TOP1)
ADC 1-2 linker
 [2]
 ADC Info 
ADC1-4
ADC 1-4 payload
DNA topoisomerase 1 (TOP1)
ADC 1-4 linker
 [2]
 ADC Info 
ADC1-11
ADC 1-11 payload
DNA topoisomerase 1 (TOP1)
ADC 1-11 linker
 [2]
 ADC Info 
ADC1-1
ADC 1-1 payload
DNA topoisomerase 1 (TOP1)
ADC 1-1 linker
 [2]
 ADC Info 
ADC1-12
ADC 1-12 payload
DNA topoisomerase 1 (TOP1)
ADC 1-12 linker
 [2]
References
Ref 1 MTX-13, a Novel PTK7-Directed Antibody-Drug Conjugate with Widened Therapeutic Index Shows Sustained Tumor Regressions for a Broader Spectrum of PTK7-Positive Tumors
Ref 2 Antibody drug conjugates; 2023-07-06.