Antigen Information
General Information of This Antigen (ID: TAR0JXPTV)
| Antigen Name | Inactive tyrosine-protein kinase 7 (PTK7) |
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| Gene Name | PTK7 |
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| Gene ID | ||||||
| Synonym | CCK4; Colon carcinoma kinase 4;Protein-tyrosine kinase 7;Pseudo tyrosine kinase receptor 7;Tyrosine-protein kinase-like 7 |
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| Sequence |
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP Click to Show/Hide
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| Family | Tyr protein family |
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| Function |
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
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| Uniprot Entry | ||||||
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Ab13
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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MTX-13
[1]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
T1000 |
Anti-PTK7 antibody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
PRO1107
|
Monomethyl auristatin E |
Microtubule (MT) |
A cleavable linker |
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SKB518
|
KL610348 |
DNA topoisomerase 1 (TOP1) |
Kthiol (pyrimidine-thiol) GGFG linker |
Anti-PTK7 IgG1 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
KIVU-107
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
Anti-PTK7 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
LY4175408
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
A proprietary polysarcosine hydrophobicity linker |
Cofetuzumab
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Cofetuzumab pelidotin
|
Auristatin 0101 (Aur0101) |
Microtubule (MT) |
Mc-Val-Cit-PABC |
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ADC1-2
[2]
|
ADC 1-2 payload |
DNA topoisomerase 1 (TOP1) |
ADC 1-2 linker |
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ADC1-4
[2]
|
ADC 1-4 payload |
DNA topoisomerase 1 (TOP1) |
ADC 1-4 linker |
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ADC1-11
[2]
|
ADC 1-11 payload |
DNA topoisomerase 1 (TOP1) |
ADC 1-11 linker |
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ADC1-1
[2]
|
ADC 1-1 payload |
DNA topoisomerase 1 (TOP1) |
ADC 1-1 linker |
|
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ADC1-12
[2]
|
ADC 1-12 payload |
DNA topoisomerase 1 (TOP1) |
ADC 1-12 linker |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
DEC006
|
CPT113 |
DNA topoisomerase 1 (TOP1) |
Highly stable yet cleavable linker |
References