General Information of This Antigen
Antigen ID
TAR0JNSUE
Antigen Name
Hepatitis A virus cellular receptor 1 (HAVCR1)
Gene Name
HAVCR1
Synonym
KIM1; TIM1; TIMD1; Kidney injury molecule 1;T-cell immunoglobulin and mucin domain-containing protein 1;T-cell immunoglobulin mucin receptor 1;T-cell membrane protein 1;CD_antigen=CD365
Sequence
MHPQVVILSLILHLADSVAGSVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNG
IVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITV
SLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPMTTVPTTTVPTTMSIPTTTTVLT
TMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPT
TLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGIYAGV
CISVLVLLALLGVIIAKKYFFKKEVQQLSVSFSSLQIKALQNAVEKEVQAEDNIYIENSL
YATD

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Family
TIM family
Function
Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P- selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti- inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation. May play a role in kidney injury and repair.

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Uniprot Entry
HAVR1_HUMAN
HGNC ID
HGNC:17866
KEGG ID
hsa:26762
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
CDX-014
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC