Antigen Information
General Information of This Antigen (ID: TAR0INITZ)
| Antigen Name | Beta-2-microglobulin (B2M) |
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| Gene Name | B2M |
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| Gene ID | ||||||
| Sequence |
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM Click to Show/Hide
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| Family | ATR family |
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| Function |
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
LS-B2200
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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B2M-duocarmycin ADC
[1]
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Duocarmycin A |
Human Deoxyribonucleic acid (hDNA) |
Bis-Tolylsulfonyl-Propanoyl-Benzamide-Glu-NH-PEG(24u)-OMe-Val-Cit-PAB |
References