Antigen Information

General Information of This Antigen
Antigen ID
TAR0INITZ
Antigen Name
Beta-2-microglobulin (B2M)
Gene Name
B2M
Gene ID
567
Sequence
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

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Family
ATR family
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.

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Uniprot Entry
B2MG_HUMAN
HGNC ID
HGNC:914
KEGG ID
hsa:567
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
B2M-duocarmycin ADC
Duocarmycin A
Human Deoxyribonucleic acid (hDNA)
Bis-Tolylsulfonyl-Propanoyl-Benzamide-Glu-NH-PEG(24u)-OMe-Val-Cit-PAB
 [1]
References
Ref 1 Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker. Sci Rep. 2021 Oct 13;11(1):20358. doi: 10.1038/s41598-021-99852-2.