Antigen Information

General Information of This Antigen (ID: TAR0GSSJV)
Antigen Name
Pregnancy-specific beta-1-glycoprotein 2 (PSG2)
Gene Name
PSG2
Gene ID
5670
Synonym
PSBG2; Pregnancy-specific beta-1 glycoprotein E
Sequence
MGPLSAPPCTEHIKWKGLLVTASLLNFWNLPTTAQVTIEAQPPKVSEGKDVLLLVHNLPQ
NLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETAYSNASLLIQNVTREDAGSY
TLHIIKRGDGTRGVTGYFTFTLYLETPKPSISSSNLNPREAMETVILTCDPETPDTSYQW
WMNGQSLPMTHRFQLSETNRTLFLFGVTKYTAGPYECEIRNSGSASRSDPVTLNLLHGPD
LPRIHPSYTNYRSGDNLYLSCFANSNPPAQYSWTINGKFQQSGQNLFIPQITTKHSGLYV
CSVRNSATGEESSTSLTVKVSASTRIGLLPLLNPT

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Family
BTN/MOG family
Uniprot Entry
PSG2_HUMAN
HGNC ID
HGNC:9519
KEGG ID
hsa:5670
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CEA mAb MIC0101
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Fluorescent Antibody-Drug Conjugate [1]
Paclitaxel
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-CEACAM5 mAb A5B7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Monoclonal antibody A5B7-cisplatin conjugate [2]
Cisplatin
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
CytSCA208 [3]
Cytorhodin S
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CEA ADC [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Development and Evaluation of a Fluorescent Antibody-Drug Conjugate for Molecular Imaging and Targeted Therapy of Pancreatic Cancer. PLoS One. 2016 Jun 23;11(6):e0157762. doi: 10.1371/journal.pone.0157762. eCollection 2016.
Ref 2 Pharmacokinetics and tissue distribution of cisplatin and conjugates of cisplatin with carboxymethyldextran and A5B7 monoclonal antibody in CD1 mice. J Pharm Sci. 1997 Dec;86(12):1478-83. doi: 10.1021/js960282u.
Ref 3 Selective killing of carcinoembryonic-antigen (CEA)-producing cells in vitro by the immunoconjugate cytorhodin-S and CEA-reactive cytorhodin-S antibody CA208. Cancer Immunol Immunother. 1989;30(4):239-46. doi: 10.1007/BF01665011.
Ref 4 Introduction to basic information on ADC drug CEA ADC