Antigen Information

General Information of This Antigen
Antigen ID
TAR0GORST
Antigen Name
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Gene Name
CTLA4
Gene ID
1493
Synonym
CD152; Cytotoxic T-lymphocyte-associated antigen 4;CD_antigen=CD152
Sequence
MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY
ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR
AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFL
LTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN

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Function
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

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Uniprot Entry
CTLA4_HUMAN
HGNC ID
HGNC:2505
KEGG ID
hsa:1493
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CTLA4 mAb clone 9D9
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CTLA4-IR700
IRDye 700DX
Undisclosed
Undisclosed
 [1]
Ipilimumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ipilimumab-Compound 9
Mertansine DM1
Microtubule (MT)
Ipilimumab-Compound 9 linker
 [2]
 ADC Info 
Ipilimumab-Compound 17
Mertansine DM4
Microtubule (MT)
Ipilimumab-Compound 17 linker
 [2]
 ADC Info 
Ipilimumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Ipilimumab-Compound 25 linker
 [2]
 ADC Info 
Ipilimumab-Compound 31
Auristatin 0101
Microtubule (MT)
Ipilimumab-Compound 31 linker
 [2]
 ADC Info 
Ipilimumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Ipilimumab-Compound 36 linker
 [2]
 ADC Info 
Ipilimumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ipilimumab-Compound 43 linker
 [2]
 ADC Info 
Ipilimumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ipilimumab-Compound 49 linker
 [2]
 ADC Info 
Ipilimumab-Compound 55
Mertansine DM1
Microtubule (MT)
Ipilimumab-Compound 55 linker
 [2]
 ADC Info 
Ipilimumab-Compound 59
Mertansine DM4
Microtubule (MT)
Ipilimumab-Compound 59 linker
 [2]
 ADC Info 
Ipilimumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Ipilimumab-Compound 64 linker
 [2]
 ADC Info 
Ipilimumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Ipilimumab-Compound 69 linker
 [2]
 ADC Info 
Ipilimumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Ipilimumab-Compound 74 linker
 [2]
 ADC Info 
Ipilimumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Ipilimumab-Compound 75 linker
 [2]
 ADC Info 
Ipilimumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Ipilimumab-Compound 76 linker
 [2]
 ADC Info 
Ipilimumab-Compound 77
Mertansine DM1
Microtubule (MT)
Ipilimumab-Compound 77 linker
 [2]
 ADC Info 
Ipilimumab-Compound 78
Auristatin 0101
Microtubule (MT)
Ipilimumab-Compound 78 linker
 [2]
 ADC Info 
Ipilimumab-Compound 79
Auristatin 0101
Microtubule (MT)
Ipilimumab-Compound 79 linker
 [2]
 ADC Info 
Ipilimumab-Compound 80
Mertansine DM4
Microtubule (MT)
Ipilimumab-Compound 80 linker
 [2]
 ADC Info 
Ipi-DM1 38127423
Mertansine DM1
Microtubule (MT)
Undisclosed
 [3]
 ADC Info 
Ipi-DM1 36909522
Mertansine DM1
Microtubule (MT)
Undisclosed
 [4]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CTLA-4-targeted ETB
Undisclosed
Undisclosed
Undisclosed
 [5]
 ADC Info 
ADC CTLA4 Toxin
Undisclosed
Undisclosed
Undisclosed
 [6]
References
Ref 1 Simultaneously Combined Cancer Cell- and CTLA4-Targeted NIR-PIT Causes a Synergistic Treatment Effect in Syngeneic Mouse Models. Mol Cancer Ther. 2021 Nov;20(11):2262-2273. doi: 10.1158/1535-7163.MCT-21-0470. Epub 2021 Sep 13.
Ref 2 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 3 CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Ref 4 CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Ref 5 Preclinical characterization of a novel CTLA-4-targeted ETB for direct Treg depletion. Cancer Res (2021) 81 (13_Supplement): 1627.
Ref 6 Introduction to basic information on anti CTLA4 antibody drug conjugate (Lanier Biotherapeutics).