Antigen Information
General Information of This Antigen
| Antigen ID | TAR0GODDK |
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| Antigen Name | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) |
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| Gene Name | ST8SIA1 |
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| Gene ID | ||||||
| Synonym | SIAT8A; Alpha-2,8-sialyltransferase 8A;Ganglioside GD3 synthase;Ganglioside GT3 synthase;Sialyltransferase 8A;Sialyltransferase St8Sia I |
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| Sequence |
MSPCGRARRHTSRGAMAVLAWKFPRTRLPVGASALCVVVLCWLYVFPVYRLPDEKEIVQG
VLQQGTAWRRNRTAAGIFRKQMEDCCDPAHLFAMTKMNAPMGKSLWYDGEFLYSFTIDNS TYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEADFVMRCNLPPLSSEYTKDVGS KSHLVTANPSIIRQRFQNLLWSRKTFVDHMKVYNHSYIYMPAFSMKTGTEPSLRVYYTLS DVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSV NMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDNSLQPTS Click to Show/Hide
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| Family | GDNFR family |
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| Function |
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively.
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| Uniprot Entry | ||||||
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Each Antibody-drug Conjuate AND It's Component Related to This Antigen