Antigen Information

General Information of This Antigen (ID: TAR0FWJCJ)
Antigen Name
Urokinase plasminogen activator surface receptor (PLAUR)
Gene Name
PLAUR
Gene ID
5329
Synonym
MO3; UPAR; Monocyte activation antigen Mo3;CD87
Sequence
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLM.LWGGTLLWT

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Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

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Uniprot Entry
UPAR_HUMAN
HGNC ID
HGNC:9053
KEGG ID
hsa:5329
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-PLAUR mAb 2G10
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2G10 RED-106 maytansine 2 [1]
Mertansine DM1
Microtubule (MT)
RED-106
 ADC Info 
2G10 RED-106 maytansine 4 [1]
Mertansine DM1
Microtubule (MT)
RED-106
 ADC Info 
2G10 RED-425 maytansine 4 [1]
Mertansine DM1
Microtubule (MT)
RED-425
 ADC Info 
2G10 RED-432 maytansine 4 [1]
Mertansine DM1
Microtubule (MT)
RED-432
 ADC Info 
2G10 RED-244 MMAE 2 [1]
Monomethyl auristatin E
Microtubule (MT)
RED-244
 ADC Info 
2G10 RED-244 MMAE 4 [1]
Monomethyl auristatin E
Microtubule (MT)
RED-244
 ADC Info 
2G10 RED-412 MMAE 4 [1]
Monomethyl auristatin E
Microtubule (MT)
RED-412
 ADC Info 
2G10 RED-388 MMAE 4 [1]
Monomethyl auristatin E
Microtubule (MT)
RED-388
 ADC Info 
2G10 RED-426 MMAE 4 [1]
Monomethyl auristatin E
Microtubule (MT)
RED-426
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EDC-4 [2]
Glycosylation scillarenin
Undisclosed
CEN010-105
 ADC Info 
References
Ref 1 Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 5;8(4):54. doi: 10.3390/antib8040054.
Ref 2 Introduction to basic information on ADC drug EDC-4