Antigen Information

General Information of This Antigen
Antigen ID
TAR0FWJCJ
Antigen Name
Urokinase plasminogen activator surface receptor (PLAUR)
Gene Name
PLAUR
Gene ID
5329
Synonym
MO3; UPAR; Monocyte activation antigen Mo3;CD_antigen=CD87
Sequence
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLM.LWGGTLLWT

    Click to Show/Hide
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

    Click to Show/Hide
Uniprot Entry
UPAR_HUMAN
HGNC ID
HGNC:9053
KEGG ID
hsa:5329
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-PLAUR mAb 2G10
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
2G10 RED-106 maytansine 2
Mertansine DM1
Microtubule (MT)
RED-106
 [1]
 ADC Info 
2G10 RED-106 maytansine 4
Mertansine DM1
Microtubule (MT)
RED-106
 [1]
 ADC Info 
2G10 RED-425 maytansine 4
Mertansine DM1
Microtubule (MT)
RED-425
 [1]
 ADC Info 
2G10 RED-432 maytansine 4
Mertansine DM1
Microtubule (MT)
RED-432
 [1]
 ADC Info 
2G10 RED-244 MMAE 2
Monomethyl auristatin E
Microtubule (MT)
RED-244
 [1]
 ADC Info 
2G10 RED-244 MMAE 4
Monomethyl auristatin E
Microtubule (MT)
RED-244
 [1]
 ADC Info 
2G10 RED-412 MMAE 4
Monomethyl auristatin E
Microtubule (MT)
RED-412
 [1]
 ADC Info 
2G10 RED-388 MMAE 4
Monomethyl auristatin E
Microtubule (MT)
RED-388
 [1]
 ADC Info 
2G10 RED-426 MMAE 4
Monomethyl auristatin E
Microtubule (MT)
RED-426
 [1]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
EDC-4
Glycosylation scillarenin
Undisclosed
CEN010-105
 [2]
References
Ref 1 Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer. Antibodies (Basel). 2019 Nov 5;8(4):54. doi: 10.3390/antib8040054.
Ref 2 Introduction to basic information on ADC drug EDC-4