Antigen Information

General Information of This Antigen
Antigen ID
TAR0FKDXJ
Antigen Name
Interleukin-1 receptor type 2 (IL1R2)
Gene Name
IL1R2
Gene ID
7850
Synonym
IL1RB; CD121 antigen-like family member B;CDw121b;IL-1 type II receptor;Interleukin-1 receptor beta;Interleukin-1 receptor type II;CD_antigen=CD121b
Sequence
MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS
VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS
IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN
EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII
SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE
NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA
FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK

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Family
Integrin beta chain family
Function
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

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Uniprot Entry
IL1R2_HUMAN
HGNC ID
HGNC:5994
KEGG ID
hsa:7850
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-Tac (Fv)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-Tac (Fv)-PE38KDEL conjugate
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [1]
References
Ref 1 Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma. Blood. 1994 Jan 15;83(2):426-34.