Antigen Information
General Information of This Antigen (ID: TAR0FKDXJ)
| Antigen Name | Interleukin-1 receptor type 2 (IL1R2) |
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| Gene Name | IL1R2 |
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| Synonym | IL1RB; CD121 antigen-like family member B;CDw121b;IL-1 type II receptor;Interleukin-1 receptor beta;Interleukin-1 receptor type II;CD121b |
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| Sequence |
MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWAS
VSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMS IELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDN EKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVII SPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSE NNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLA FLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK Click to Show/Hide
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| Family | Integrin beta chain family |
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| Function |
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
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Anti-Tac (Fv)
| ADC Name | Payload | Target | Linker | ADC Info |
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Anti-Tac (Fv)-PE38KDEL conjugate
[1]
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Pseudomonas exotoxin PE38 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
References