Antigen Information

General Information of This Antigen
Antigen ID
TAR0EPIEB
Antigen Name
C-X-C chemokine receptor type 5 (CXCR5)
Gene Name
CXCR5
Gene ID
643
Synonym
BLR1; MDR15; Burkitt lymphoma receptor 1;Monocyte-derived receptor 15;CD_antigen=CD185
Sequence
MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSL
IFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTF
LCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLL
ALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVG
VVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSL
PVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSL
SESENATSLTTF

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Family
Glypican family
Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

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Uniprot Entry
CXCR5_HUMAN
HGNC ID
HGNC:1060
KEGG ID
hsa:643
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024105205A1 1x-9574
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 4x-9574
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 6x-9574
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 7x-9574
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 11x-9574b
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 12x-9574a 1
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 12x-9574a 2
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 13x-9574
KSPI6-1
Undisclosed
Undisclosed
 [1]
 ADC Info 
WO2024105205A1 14x-9574
KSPI6-1
Undisclosed
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024105205A1 3x-9574*
KSPI6-1
Undisclosed
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024105205A1 11x-9574a
KSPI6-1
Undisclosed
Undisclosed
 [1]
Anti-CXCR5 IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BAY-924
KSP inhibitor
Kinesin-like protein KIF11 (KIF11)
Undisclosed
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN110072556B 1x-9024
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 [3]
 ADC Info 
R1x-9024
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN110072556B 1x-9574
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 [3]
 ADC Info 
R1x-9574
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN110072556B 1x-9580
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 [3]
 ADC Info 
R1x-9580
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 [3]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CXCR5 monoclonal antibody-drug conjugate
Undisclosed
Undisclosed
Undisclosed
 [4]
References
Ref 1 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 2 Preclinical characterization of BAY-924, a first in class ADC targeting CXCR5-positive B-cell malignancies, with a KSP inhibitor as novel payload. Cancer Res (2019) 79 (13_Supplement): 4825.
Ref 3 Specific antibody-drug conjugates (ADCs) having KSP inhibitors
Ref 4 Introduction to basic information on ADC drug CXCR5 monoclonal antibody-drug conjugate.