Antigen Information

General Information of This Antigen (ID: TAR0EPIEB)
Antigen Name
C-X-C chemokine receptor type 5 (CXCR5)
Gene Name
CXCR5
Gene ID
643
Synonym
BLR1; MDR15; Burkitt lymphoma receptor 1;Monocyte-derived receptor 15;CD185
Sequence
MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSL
IFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTF
LCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLL
ALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVG
VVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSL
PVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSL
SESENATSLTTF

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Family
Glypican family
Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

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Uniprot Entry
CXCR5_HUMAN
HGNC ID
HGNC:1060
KEGG ID
hsa:643
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1x-9574 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 4x-9574 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 6x-9574 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 7x-9574 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 11x-9574b [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12x-9574a 1 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12x-9574a 2 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 13x-9574 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 14x-9574 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 3x-9574* [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 11x-9574a [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
Anti-CXCR5 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BAY-924 [2]
KSP inhibitor
Kinesin-like protein KIF11 (KIF11)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN110072556B 1x-9024 [3]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 ADC Info 
R1x-9024 [3]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN110072556B 1x-9574 [3]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 ADC Info 
R1x-9574 [3]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN110072556B 1x-9580 [3]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+Conjugate1+Linker
 ADC Info 
R1x-9580 [3]
KSP Inhbitor
Kinesin spindle protein (KSP)
CN110072556B+ConjugateR1+Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CXCR5 monoclonal antibody-drug conjugate [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 2 Preclinical characterization of BAY-924, a first in class ADC targeting CXCR5-positive B-cell malignancies, with a KSP inhibitor as novel payload. Cancer Res (2019) 79 (13_Supplement): 4825.
Ref 3 Specific antibody-drug conjugates (ADCs) having KSP inhibitors
Ref 4 Introduction to basic information on ADC drug CXCR5 monoclonal antibody-drug conjugate.