Antigen Information
General Information of This Antigen (ID: TAR0DSBFQ)
| Antigen Name | Stage-specific embryonic antigen-4 (SSEA-4) |
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|---|---|---|---|---|---|---|
| Function |
SSEA-4, a sialic acid-containing glycolipid, is recognized as a specific marker for pluripotent stem cells, and is reportedly a useful marker for the detection of CSCs. Furthermore, SSEA-4 expression has been associated with the remodeling of gastrointestinal cancer cell lines including those in esophageal, stomach, colorectal, liver, pancreatic, and cholangiocellular cancer. In addition, SSEA-4 expression is positively associated with malignant behavior in breast cancer and glioblastoma.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
OBI-898
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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OBI-998
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
Maleimide and PEGylated cleavable linker |
References