Antigen Information

General Information of This Antigen
Antigen ID
TAR0DQDFY
Antigen Name
CD276 antigen (CD276); Hepatocyte growth factor receptor (MET)
Gene Name
CD276; MET
Synonym1
B7H3; PSEC0249; UNQ309; PRO352; 4Ig-B7-H3;B7; homolog; 3;Costimulatory; molecule;CD_antigen=CD276
Synonym2
HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;Tyrosine-protein kinase Met
Sequence1
MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL
AQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSF
TCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQD
GQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQ
RSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEG
RDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPY
SKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLF
DVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIAL
LVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA

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Sequence2
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS

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Family1
HIV-1 env protein family
Family2
Tyr protein family
Function1
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

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Function2
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis.

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Uniprot Entry
CD276_HUMAN , MET_HUMAN
HGNC ID
HGNC:19137 , HGNC:7029
KEGG ID
hsa:80381 , hsa:4233
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-B7-H3 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BB-1712
Eribulin
Microtubule (MT)
A cleavable linker
 [1]
Anti-B7H3 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Vobramitamab tavatecan
Exatecan
DNA topoisomerase 1 (TOP1)
Synaffix linker
 ADC Info 
MHB088C
MH30010008
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ILB-3101
Eribulin
Microtubule (MT)
A cleavable linker
 ADC Info 
DB-1311
P1021
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
BAT8009
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
7MW3711
Mtoxin
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [2]
 ADC Info 
BGB-C354
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [3]
 ADC Info 
iCP-B794
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
sYS6043
JS-1
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
sKB500
KL610348
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
iTC-6146RO
Duocarmycin derivative
Human deoxyribonucleic acid (hDNA)
Self-immolative OHPAS linker
B7H3/cMET bispecific antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SCR-A0011
CPT116
Undisclosed
Undisclosed
 [4]
Ifinatamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ifinatamab deruxtecan
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
Mirzotamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Mirzotamab clezutoclax
Clezutoclax
Bcl-2-like protein 1 (BCL2L1)
Val-Ala dipeptide linker
Risvutatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Risvutatug rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
Tambotatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Tambotatug pelitecan
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
Vobramitamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Vobramitamab duocarmazine
seco-DUBA
Human deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
MGC026
Exatecan
DNA topoisomerase 1 (TOP1)
Bicyclononyne carbamoyl sulfamide Val-Ala-PABC
References
Ref 1 Bliss Biopharmaceutical company product pipeline
Ref 2 Clinical Trial Application for 7MW3711 - an Innovative Drug Developed by Mabwell's ADC Platform, Accepted by NMPA.
Ref 3 BGB-C354, a novel B7H3 ADC with high DAR stability and strong bystander effect, demonstrates robust antitumor activity in preclinical models
Ref 4 SCR-A0011, a novel bispecific ADC targeting cMET and B7H3, exhibits potent anti-tumor efficacy