Antigen Information

General Information of This Antigen (ID: TAR0DJPZG)
Antigen Name
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Gene Name
ROR2
Gene ID
6095
Synonym
NTRKR2; Neurotrophic tyrosine kinase, receptor-related 2
Sequence
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY
FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL
RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI
ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD
ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC
MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG
GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC
LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG
EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL
GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA
AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA
PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW
VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN
VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV
QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA
PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA

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Family
Tyr protein family
Function
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

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Uniprot Entry
ROR2_HUMAN
HGNC ID
HGNC:10257
KEGG ID
hsa:4920
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
BAP048.7-mc-VC-PAB-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
BAP048.7-mc-PEG8-vC-PAB-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG8-Val-Cit-PAB
 ADC Info 
Ozuriftamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ozuriftamab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Ror2-CAB1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ror2-CAB1-ADC [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ror2-CAB2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ror2-CAB2-ADC [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ror2-CAB3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ror2-CAB3-ADC [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Anti-mesothelin antibodies and uses thereof
Ref 2 Treatment of cancer with conditionally active anti-ROR2 antibody-drug conjugates
Ref 3 Antibodies specifically binding MUC-1 and uses thereof