Antigen Information

General Information of This Antigen
Antigen ID
TAR0DJPZG
Antigen Name
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Gene Name
ROR2
Synonym
NTRKR2; Neurotrophic tyrosine kinase, receptor-related 2
Sequence
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY
FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL
RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI
ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD
ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC
MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG
GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC
LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG
EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL
GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA
AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA
PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW
VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN
VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV
QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA
PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA

    Click to Show/Hide
Family
Tyr protein family
Function
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

    Click to Show/Hide
Uniprot Entry
ROR2_HUMAN
HGNC ID
HGNC:10257
KEGG ID
hsa:4920
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BAP048.7-mc-VC-PAB-MMAE
Monomethyl auristatin E
Undisclosed
Mc-Val-Cit-PABC
 [1]
 ADC Info 
BAP048.7-mc-PEG8-vC-PAB-MMAE
Monomethyl auristatin E
Undisclosed
Mal-PEG8-Val-Cit-PAB
 [1]
Ror2-CAB1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ror2-CAB1-ADC
Undisclosed
Undisclosed
Undisclosed
 [2]
Ror2-CAB2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ror2-CAB2-ADC
Undisclosed
Undisclosed
Undisclosed
 [3]
Ror2-CAB3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ror2-CAB3-ADC
Undisclosed
Undisclosed
Undisclosed
 [1]
References
Ref 1 Anti-mesothelin antibodies and uses thereof
Ref 2 Treatment of cancer with conditionally active anti-ROR2 antibody-drug conjugates
Ref 3 Antibodies specifically binding MUC-1 and uses thereof