Antigen Information

General Information of This Antigen (ID: TAR0CREXX)
Antigen Name
SLIT and NTRK-like protein 6 (SLITRK6)
Gene Name
SLITRK6
Gene ID
84189
Sequence
MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS
VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN
HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF
RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS
IIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKT
TSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP
PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNG
NHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS
GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTV
TDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS
LTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSM
YGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRS
LLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIA
QLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQ
T

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Family
SLC3A transporter family
Function
Regulator of neurite outgrowth required for normal hearing and vision.

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Uniprot Entry
SLIK6_HUMAN
HGNC ID
HGNC:23503
KEGG ID
hsa:84189
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-SLITRK6 mAb Ha15-10ac14
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HA15-10AC14F [1]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
HA15-10AC14E [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-SLITRK6 mAb Ha15-1abe16
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HA15-1ABE16F [1]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
HA15-1ABE16E [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-SLITRK6 mAb Ha15-1c25
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HA15-1C25F [1]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
HA15-1C25E [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Ha15-10ac12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN111330016A ADC-1 [3]
CN111330016A ADC-1 payload
Undisclosed
CN111330016A ADC-1 linker
 ADC Info 
Sirtratumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Sirtratumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ASG-15MF [1]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
References
Ref 1 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10.
Ref 2 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10. doi: 10.1158/1535-7163.MCT-15-0570. Epub 2016 Mar 4.
Ref 3 Antibody Drug Conjugates (ADC) that bind to 158P1D7 protein.