Antigen Information

General Information of This Antigen
Antigen ID
TAR0CREXX
Antigen Name
SLIT and NTRK-like protein 6 (SLITRK6)
Gene Name
SLITRK6
Gene ID
84189
Sequence
MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS
VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN
HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF
RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS
IIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKT
TSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP
PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNG
NHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS
GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTV
TDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS
LTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSM
YGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRS
LLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIA
QLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQ
T

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Family
SLC3A transporter family
Function
Regulator of neurite outgrowth required for normal hearing and vision.

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Uniprot Entry
SLIK6_HUMAN
HGNC ID
HGNC:23503
KEGG ID
hsa:84189
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-SLITRK6 mAb Ha15-10ac14
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HA15-10AC14F
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [1]
 ADC Info 
HA15-10AC14E
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
Anti-SLITRK6 mAb Ha15-1abe16
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HA15-1ABE16F
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [1]
 ADC Info 
HA15-1ABE16E
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
Anti-SLITRK6 mAb Ha15-1c25
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HA15-1C25F
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [1]
 ADC Info 
HA15-1C25E
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
Ha15-10ac12
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN111330016A ADC-1
CN111330016A ADC-1 payload
Undisclosed
CN111330016A ADC-1 linker
 [3]
Sirtratumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Sirtratumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
 ADC Info 
ASG-15MF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [1]
References
Ref 1 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10.
Ref 2 Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker. Mol Cancer Ther. 2016 Jun;15(6):1301-10. doi: 10.1158/1535-7163.MCT-15-0570. Epub 2016 Mar 4.
Ref 3 Antibody Drug Conjugates (ADC) that bind to 158P1D7 protein.
Ref 4 ADC review: basic information about sirtratumab vedotin.

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