Antigen Information

General Information of This Antigen
Antigen ID
TAR0ADNKX
Antigen Name
Prostate stem cell antigen (PSCA)
Gene Name
PSCA
Synonym
PSCA
Sequence
MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLN
CVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL

    Click to Show/Hide
Function
FUNCTION: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. {ECO:0000269|PubMed:18488030}.; FUNCTION: May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. {ECO:0000305|PubMed:25680266}.

    Click to Show/Hide
Uniprot Entry
PSCA_HUMAN
HGNC ID
HGNC:9500 ,
KEGG ID
hsa:8000 ,
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
F12-MMAE
Monomethyl auristatin E
Undisclosed
NHS-VC-PAB
 [1]
References
Ref 1 Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer