Antigen Information

General Information of This Antigen (ID: TAR0ADNKX)
Antigen Name
Prostate stem cell antigen (PSCA)
Gene Name
PSCA
Gene ID
8000
Synonym
PSCA
Sequence
MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLN
CVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL

    Click to Show/Hide
Function
FUNCTION: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. {ECO:0000269|PubMed:18488030}.; FUNCTION: May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. {ECO:0000305|PubMed:25680266}.

    Click to Show/Hide
Uniprot Entry
PSCA_HUMAN
HGNC ID
HGNC:9500 ,
KEGG ID
hsa:8000
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
F12-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
NHS-VC-PAB
 ADC Info 
References
Ref 1 Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer